• Read more about A022104

Short Title: JANUS

This phase II trial compares the effect of irinotecan versus oxaliplatin after long-course chemoradiation in patients with stage II-III rectal cancer. Combination chemotherapy drugs, such as FOLFIRINOX (fluorouracil, irinotecan, leucovorin, and oxaliplatin), FOLFOX (leucovorin, fluorouracil, oxaliplatin, and irinotecan), and CAPOX (capecitabin and oxaliplatin) work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

Study Number:

A022104

Study Status:

Enrolling

Treatment Agent:

Capecitabine, 5-fluorouracil, Leucovorin calcium, Irinotecan, Oxaliplatin

Resources and Links

National Clinical Trial Identified Number: NCT05610163

Disease:

• Locally Advanced Rectal Carcinoma

Study Phase:

II

researchcancer@cooperhealth.edu

Index Extra:

GI, gastro, rectal

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Physician Name:

• Jamin C. Morrison, MD, MBA

Department:

• Hematology and Medical Oncology

• Read more about SURVENT

Short Title: SURVENT 

The trial’s primary aim is to determine if patients undergoing endoscopic eradication therapy will demonstrate less neoplastic progression and a lower incidence of esophageal adenocarcinoma compared to patients undergoing surveillance. 

Study Number:

SURVENT

Study Status:

Enrolled

Treatment Agent:

Not Applicable

Resources and Links

National Clinical Trial Identified Number: NCT05753748

Disease:

• Barrett’s Esophagus with Low-grade Dysplasia,
• Esophageal Adenocarcinoma

Study Phase:

Not Applicable

researchcancer@cooperhealth.edu

Index Extra:

Esophageal, head and neck, Dysplasia, Barrett’s, Esophagus, gastro

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Physician Name:

• Anthony Infantolino, MD, FACP, FACG, AGAF, MASGE

Department:

• Gastroenterology

• Read more about SOROCk

Short Title: SOROCk

This clinical trial studies how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.

Study Number:

CC008

Study Status:

Enrolling

Treatment Agent:

Not Applicable

Resources and Links

National Clinical Trial Identified Number: NCT04251052

Disease:

• Ovarian Carcinoma

Study Phase:

Not Applicable

ResearchCancer@CooperHealth.edu

Index Extra:

Ovarian, gyn, Gynecologic

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Physician Name:

• David P. Warshal, MD, FACOG

Department:

• Gynecologic Cancer Center

• Read more about SAMURAI

Short Title: SAMURAI

This phase II trial tests whether the addition of radiation to the primary tumor, typically given with stereotactic ablative radiation therapy (SABR), in combination with standard of care immunotherapy improves outcomes in patients with renal cell cancer that is not recommended for surgery and has spread to other places in the body (metastatic).

Study Number:

GU012

Study Status:

Enrolling

Treatment Agent:

Avelumab, Axitinib, Cabozantinib, Ipilimumab, Lenvatinib, Nivolumab, Pembrolizumab

Resources and Links

National Clinical Trial Identified Number: NCT05327686

Disease:

• Metastatic Renal Cell Carcinoma,
• Unresectable Renal Cell Carcinoma

Study Phase:

II

researchcancer@cooperhealth.edu

Index Extra:

GU, Renal

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Physician Name:

• Gary A. Eastwick, MD

Department:

• Radiation Oncology

• Read more about PDX

Short Title: PDX

To establish a continuously expanded library of human-to-mouse tumor grafts and cell lines from recalcitrant carcinomas, sarcomas or other malignancies.

Study Number:

PDX

Study Status:

Enrolling

Treatment Agent:

Not Applicable

Resources and Links

National Clinical Trial Identified Number: N/A

Disease:

• Acute Myeloid Leukemia,
• Bile Duct Cancer,
• Bladder,
• Breast,
• Colorectal,
• Esophageal,
• Gallbladder,
• Gastric,
• Kidney,
• Liver,
• Lung,
• Lymphoma,
• Melanoma,
• Multiple Myeloma,
• Pancreatic,
• Prostate,
• Thyroid

Study Phase:

Not Applicable

ResearchCancer@CooperHealth.edu

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Physician Name:

• Young Ki Hong, MD, MPH, FACS, FSSO

Department:

• Surgical Oncology,
• Hematology and Medical Oncology

• Read more about IOV-MEL-301

Short Title: IOV-MEL-301

We are the first site to open this study in the world!  This study is a Phase III study of lifileucel plus pembrolizumab compared with pembrolizumab alone in participants with untreated, unresectable or metastatic melanoma. The combination has the potential for enhanced antitumor activity through the combination of programmed cell death protein-1 (PD-1) blockade allowing for optimal engraftment, increased cytotoxicity, and intratumoral expansion of the infused lifileucel product. Continued pembrolizumab therapy after lifileucel infusion is expected to perpetuate the antitumor effect.

Study Number:

IOV-MEL-301

Study Status:

Enrolling

Treatment Agent:

Lifileucel plus Pembrolizumab, Pembrolizumab with Optional Crossover Period

Resources and Links

National Clinical Trial Identified Number: NCT05727904

Disease:

• Metastatic Melanoma,
• Unresectable Melanoma

Study Phase:

III

ResearchCancer@CooperHealth.edu

Index Extra:

melanoma, skin

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Physician Name:

• Young Ki Hong, MD, MPH, FACS, FSSO

Department:

• Skin Cancer,
• Surgical Oncology

• Read more about IOV-LUN-202

Short Title: IOV-LUN-202

This study is to evaluate the efficacy of LN-145 in patients with metastatic NSCLC without an actionable driver mutation who have disease progression on or following a single line of approved systemic therapy consisting of combined immune checkpoint inhibitor(s) (CPI[s]) + chemotherapy ± bevacizumab.

Cohort 1, Cohort 2, and Cohort 4 are open:

Cohort 1: Patients whose tumors did not express programmed cell death-ligand 1 (PD-L1), ie, tumor proportion score (TPS) <1%, prior to ICI treatment and patients with no available historical TPS 

Cohort 2: Patients whose tumors expressed PD-L1 (TPS ≥1%) prior to ICI treatment 

Cohort 4: Patients, regardless of tumor PD-L1 expression status prior to ICI treatment, who had pre-progression tumor harvest 

Study Number:

IOV-LUN-202

Study Status:

Enrolling

Treatment Agent:

Lifileucel, LN-145, Pembrolizumab, LN-145-S1, Ipilimumab, Nivolumab

Resources and Links

National Clinical Trial Identified Number: NCT03645928

Disease:

• Non-Small Cell Lung Cancer

Study Phase:

II

ResearchCancer@CooperHealth.edu

Index Extra:

lung, thoracic

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Physician Name:

• Young Ki Hong, MD, MPH, FACS, FSSO

Department:

• Lung Cancer Center

• Read more about DRAMMATIC

Short Title: DRAMMATIC

This clinical trial offers treatment to patients with multiple myeloma who have undergone ASCT, a type of transplant that uses a patient's own stem cells (cells in the bone marrow that produce new blood cells) to replace those normal cells that are damaged by the high dose chemotherapy treatment that is given to kill cancer cells. Because there is a possibility of cancer returning even after ASCT, patients typically receive maintenance treatment, with the goal of preventing or delaying the return of cancer. In this clinical trial, one group of patients will be randomly assigned to receiving the standard maintenance treatment for multiple myeloma — an immunomodulatory drug called lenalidomide - which works by stimulating cells in the immune system, decreasing the blood supply to tumors, and inhibiting the growth of cancer cells.

Please note that this study is approaching the protocol specific accrual goal for Registration Step 1 and will permanently close on January 15th at 12:00 PM PST.

Study Number:

S1803

Study Status:

Enrolling

Treatment Agent:

Lenalidomide, Daratumumab/rHuPH20

Resources and Links

National Clinical Trial Identified Number: NCT04071457

Disease:

• Multiple Myeloma

Study Phase:

III

ResearchCancer@CooperHealth.edu

Index Extra:

Myeloma, HEM

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Physician Name:

• Tulin Budak-Alpdogan, MD

Department:

• Hematology and Medical Oncology

• Read more about Oral 3D Stent

Short Title: Oral 3D Stent

The primary objective of this randomized trial is to evaluate the acute mucositis rates in non-target mucosa of patients who receive head and neck radiation with or without a customized 3D printed oral stent.

Study Number:

2020-1153

Study Status:

Enrolling

Treatment Agent:

Not Applicable

Resources and Links

National Clinical Trial Identified Number: NCT04870762

Disease:

• Head and Neck Carcinoma

Study Phase:

Not Applicable

ResearchCancer@CooperHealth.edu

Index Extra:

Head and Neck

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Physician Name:

• Megan Mezera, MD

Department:

• Radiation Oncology